trisomy 4

Tumors

 acute myeloblastic leukemia (15581842, 12859991)
 acute lymphoblastic leukemia (16364773))

• B-precursor Acute Lymphoblastic Leukemia (15789069)
• T-cell acute lymphoblastic leukemia (15262438, 15041226)

Sole caryotypic anomaly

 T-cell acute lymphoblastic leukemia (15262438)

References

 Yip SF, Wan TS, Chan LC, Chan GC. Trisomy 4 as sole karyotypic abnormality in acute lymphoblastic leukemia: different clinical features and treatment response between B and T phenotypes? Cancer Genet Cytogenet. 2006 Jan 1;164(1):94-5. PMID: 16364773

 Sutcliffe MJ, Shuster JJ, Sather HN, Camitta BM, Pullen J, Schultz KR, Borowitz MJ, Gaynon PS, Carroll AJ, Heerema NA. High concordance from independent studies by the Children’s Cancer Group (CCG) and Pediatric Oncology Group (POG) associating favorable prognosis with combined trisomies 4, 10, and 17 in children with NCI Standard-Risk B-precursor Acute Lymphoblastic Leukemia: a Children’s Oncology Group (COG) initiative. Leukemia. 2005 May;19(5):734-40. PMID: 15789069

 Receveur A, Ong J, Merlin L, Azgui Z, Merle-Beral H, Berger R, Nguyen-Khac F. Trisomy 4 associated with double minute chromosomes and MYC amplification in acute myeloblastic leukemia. Ann Genet. 2004 Oct-Dec;47(4):423-7. PMID: 15581842

 Gupta V, Chun K. Trisomy 4 as the sole cytogenetic abnormality in a patient with T-cell acute lymphoblastic leukemia. Cancer Genet Cytogenet. 2004 Jul 15;152(2):158-62. PMID: 15262438

 Al-Qurashi FH, Owaidah T, Iqbal MA, Aljurf M. Trisomy 4 as the sole karyotypic abnormality in a case of acute biphenotypic leukemia with T-lineage markers in minimally differentiated acute myelocytic leukemia.
Cancer Genet Cytogenet. 2004 Apr 1;150(1):66-9. PMID: 15041226

 Gupta V, Minden MD, Yi QL, Brandwein J, Chun K. Prognostic significance of trisomy 4 as the sole cytogenetic abnormality in acute myeloid leukemia. Leuk Res. 2003 Nov;27(11):983-91. PMID: 12859991