Blood and immunity

• Langerhans cell histiocytosis
  24 October 2003

  Definition : Langerhans cell histiocytosis (histiocytosis X) is a disorder of unknown etiology characterized by solitary (eosinophilic granuloma) or multiple bone and visceral masses.
  Cytologically, the smears are hypercellular with numerous Langerhans cell histiocytes, which are large, polygonal cells with eosinophilic cytoplasm and oval nuclei with longitudinal grooves (‘coffee bean nuclei’).
  Scattered eosinophils, mixed inflammatory cells, osteoclast-like giant cells, and necrosis are (...)

• monocytes
  24 October 2003

  Definition: Monocytes are circulating phagocytic white blood cells that develop into macrophages when they enter tissues.
  Immunophenotype
  CD11b+
  CD11c+
  CD18+
  CD62L+
  CD103+
  Variants
  plasmacytoid monocytes (interferon-producing monocytes - IPCs)

• siderophages
  24 October 2003
• extranodal histiocytic sarcoma
  24 October 2003

  histiocytic lymphoma

• macrophages
  24 October 2003

  Adj. macrophagic . Histocytes WKP
  See also : histiocytes
  Images
  sea-blue histiocytes https://twitter.com/KyleBradleyMD/status/748512208993271808
  leishmania bodies in macrophages https://twitter.com/JCandidoXavier/status/1509085650066284545
  Macrophages exist in almost all animals. In some invertebrates, mesenchymal cells, endothelial cells or fibroblast-like cells can transform into macrophages.
  In vertebrates, primitive macrophages first develop in yolk sac hematopoiesis and (...)

• sinus histiocytosis with massive lymphadenopathy
  24 October 2003

  Rosai-Dorfman disease, Destombes disease

• hemophagocytosis
  21 October 2003

  erythrophagocytosis
  lymphocytophagocytosis
  neutrophagocytosis
  See also
  macrophagic activation syndrome

• erythrophagocytosis
  21 October 2003

  Definition: Phagocytosis of erythrocytes.
  Images
  Erythrophagocytosis https://twitter.com/VijayPatho/status/855299729621635073 https://twitter.com/BiopsyMD/status/831611424468242434
  hepatic erythrophagocytosis in hemophagocytic lymphohistiocytosis https://twitter.com/GIPathologyURMC/status/889533077118214144
  Etiology
  eythrophagocytosis by activated histiocytes erythrophagocytic histiocytosis macrophagic activation syndrome familial lymphohistiocytosis (...)

• macrophage activation syndrome
  21 October 2003

  histiocytosis with erythrophagocytosis, erythrophagocytic histiocytosis, hemophagocytic syndrome (HPS); hemophagocytic lymphohistiocytosis (HLH)

• Erdheim-Chester disease
  8 October 2003

  Ent. Chester, 1930. Nom. Chester, 1930.
  Definition: Erdheim-Chester disease is a very rare xanthogranulomatous, non-Langerhans cell systemic histiocytosis with an unknown etiology and pathogenesis. It involves the marrow space of the long bones.
  Extraosseous sites most commonly affected include the eyes, lungs, pituitary glands, and kidneys.
  Images
  50 year old man with bone pain and bilateral symmetrical sclerotic lesions on plain films of his femurs (...)

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