B. Cellular pathology

• intermediate filaments
  10 November 2003

  Cytoplasmic intermediate filaments (IF) can be divided into 5 subclasses based on their biochemical properties, immunologic specificity and tissue distribution: keratins in epithelial cells, vimentin, desmin in muscle cells, glial filaments (GFAP) in astrocytes, and neurofilaments in neurons. The different types of intermediate filament proteins share common structural features.
  Intermediate filament proteins constitute a highly diverse family of fibrous proteins in metazoans, which (...)

• cell survival
  10 November 2003

  cellular survival

• protein trafficking
  3 November 2003

  Features
  secretory protein trafficking
  References
  Karcher RL, Deacon SW, Gelfand VI. Motor-cargo interactions : the key to transport specificity. Trends Cell Biol. 2002 Jan ;12(1):21-7. PMID : #11854006#

• secretory pathway
  30 October 2003

  There are two main classes of traffic intermediates that operate in intracellular trafficking pathways: small round vesicles, and large pleiomorphic carriers (LPCs).
  large pleiomorphic carriers (LPCs)
  While both are essential, the LPCs appear to be responsible for moving the bulk of the secretory traffic between distant compartments.
  LPCs are much larger and more variable in shape than vesicles, and they have evident interconnected tubular and saccular/cisternal components.
  LPCs appear (...)

• centrosome
  29 October 2003

  centrosomes. Adj. centrosomal

• ribosomes
  29 October 2003

  Adj. ribosomal

• secretory lysosomes
  29 October 2003

  Types
  lytic granules of cytotoxic T lymphocyte (secretory lysosomes containing both perforin and granzymes)
  melanosomes of melanocytes
  References
  Stinchcombe J, Bossi G, Griffiths GM. Linking albinism and immunity: the secrets of secretory lysosomes. Science. 2004 Jul 2;305(5680):55-9. PMID: #15232098#
  Clark R, Griffiths GM. Lytic granules, secretory lysosomes and disease. Curr Opin Immunol. 2003 Oct;15(5):516-21. PMID: #14499259#
  Huizing M, Gahl WA. Disorders of vesicles of (...)

• cytotoxic granules
  29 October 2003

  lytic granules

• vesicles
  29 October 2003

  Types
  endocytic vesicles clathrin-coated vesicles vesicular coat proteins
  exocytic vesicles (secretion vesicles)
  clathrin-coated vesicles
  transport vesicles cargo vesicles
  secretory lysosomes melanosomes
  synaptic vesicles
  secretion vesicles
  Features
  vesicular coat proteins
  References
  Graham TR. Flippases and vesicle-mediated protein transport. Trends Cell Biol. 2004 Dec;14(12):670-7. PMID: (...)

• nuclear compartmentalization
  29 October 2003

  References
  Stein GS, Zaidi SK, Braastad CD, Montecino M, van Wijnen AJ, Choi JY, Stein JL, Lian JB, Javed A. Functional architecture of the nucleus: organizing the regulatory machinery for gene expression, replication and repair. Trends Cell Biol. 2003 Nov;13(11):584-92. PMID: #14573352#
  Cremer T, Cremer C. Chromosome territories, nuclear architecture and gene regulation in mammalian cells. Nat Rev Genet. 2001 Apr;2(4):292-301. PMID: #11283701#
  Francastel C, Schubeler D, Martin DI, (...)

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