B. Cellular pathology

• chemosensation
  25 November 2003

  References
  Prasad BC, Reed RR. Chemosensation: molecular mechanisms in worms and mammals. Trends Genet. 1999 Apr;15(4):150-3. PMID: #10203825#

• kinetochore
  24 November 2003

  Kinetochores are large protein complexes that are formed on chromosome regions known as centromeres. For high-fidelity chromosome segregation, kinetochores must be correctly captured on the mitotic spindle before anaphase onset.
  Segregation of the replicated genome during cell division in eukaryotes requires the kinetochore to link centromeric DNA to spindle microtubules.
  The kinetochore is composed of a number of conserved protein complexes that direct its specification and assembly, (...)

• primary ciliary dyskinesia
  23 November 2003

  PCD, immotile cilia syndrome
  Digital case (Digital slides)
  HPC:366 : Bronchiectasis in ciliary dyskinesia
  Definition: Autosomal recessive chronic pulmonary disease.
  Synopsis
  bronchiectasis
  immotile cilia
  ciliary dyskinesia
  chronic rhinitis
  sinusitis
  nasal polyps
  abnormal dynein arms by electron microscopy
  Etiology: 5 loci have been identified. DNAI1 CILD1 MIM.242650 9p21-p13 unknown CILD2 MIM.606763 19q13.3-qter DNAH5 CILD3 MIM.608644 5p15-p14 unknown CILD4 (...)

• aneuploidy
  23 November 2003

  chromosomal aneuploidy

• cilia
  20 November 2003

  cilias, cilium WKP
  Definition: Cilia (and flagella) are microtubule-based hair-like organelles that extend from the surface of almost all cell types of the human body.
  Although these highly conserved structures are found across a broad range of species, a nearly ubiquitous appearance is observed only in vertebrates.
  Cilia can be structurally divided into subcompartments that include a basal body, transition zone, axoneme, ciliary membrane and the ciliary tip.
  Most cell types (...)

• reprogramming
  20 November 2003

  epigenetic reprogramming, nuclear reprogramming, cellular reprogramming
  Types
  epigenetic reprogramming
  nuclear reprogramming
  cellular reprogramming
  Journals
  Cellular Reprogramming (ISSN: 2152-4971 • Bimonthly • Online ISSN: 2152-4998), Mary Ann Liebert, Inc.
  References
  Hendrix MJ, Seftor EA, Seftor RE, Kasemeier-Kulesa J, Kulesa PM, Postovit LM. Reprogramming metastatic tumour cells with embryonic microenvironments. Nat Rev Cancer. 2007 Apr;7(4):246-55. PMID: #17384580#
  Hansis (...)

• chromatin remodeling diseases
  20 November 2003

  chromatin remodeling disorders

• multipotent germline stem cell
  14 November 2003

  multipotent germline stem cells, MGSCs

• cellular volume
  11 November 2003

  Pathology (Anomales of cellular volume)

• mechanosensitivity
  11 November 2003

  cell mechanosensation, cell mechanosensing, cell mechanosensitivity

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