gastric endocrine cells
Endocrine cells of the gastric oxyntic mucosa, and especially the enterochromaffin-like (ECL) cells, are the progenitors of gastrin-promoted proliferative lesions whose tumorigenic potential largely depends on the background condition in which they arise.
Pathology
gastric endocrine cell hyperplasia
gastric carcinoid tumor
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Stomach
Adj. gastric
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gastric endocrine cell
30 April 2013 -
gastric carcinoma with lymphoid stroma
16 February 2013Gastric carcinoma with lymphoid stroma (medullary carcinoma)
Gastric carcinoma with lymphoid stroma (medullary carcinoma) is one of the uncommon subtypes. It occurs more commonly in proximal stomach and generally follows a less aggressive clinical course.
Histologically, this type of carcinoma is characterized by a sharply demarcated advancing margins composed of irregular nests or sheets of polygonal tumor cells associated with a prominent lymphoid infiltrate in a non-desmoplasticstroma. (...) -
gastric signet ring cell carcinoma
16 February 2013Signet ring cell adenocarcinoma
Signet ring cell carcinoma and other poorly cohesive carcinomas are often composed of a mixture of signet ring cells and non-signet ring cells.
Poorly cohesive non-signet ring tumor cells are those that morphologically resemble histiocytes, lymphocytes, and plasma cells.
Those tumor cells can form irregular microtrebaculae or lace-like abortive glands, often accompanied by marked desmoplasia in the gastric wall and with a grossly depressed or ulcerated (...) -
gastric mucinous adenocarcinoma
16 February 2013Mucinous adenocarcinoma accounts for 10% of gastric carcinoma. Histologically it is characterized by extracellular mucinous pools which constitute at least 50% of tumor volume.
The tumor cells can form glandular architecture and irregular cell clusters, with occasional scattered signet ring cells floating in the mucinous pools. -
gastric tubular adenocarcinoma
16 February 2013Tubular adenocarcinoma is the most common histologic type of early gastric carcinoma.
It tends to form polypoid or fungating masses grossly, and histologically demonstrates irregularly distended, fused or branching tubules of various sizes, often with intraluminal mucus, nuclear and inflammatory debris. -
The advanced gastric carcinoma which invades...
16 February 2013The advanced gastric carcinoma which invades into muscularispropria or beyond carries a much worse prognosis, with a 5 years survival rate at about 60% or less.
The gross appearance of advanced gastric carcinomas can be exophytic, ulcerated, infiltrative or combined.
Based on Borrmann’s classification, the gross appearance of advanced gastric carcinomas can be divided into:
type I for polypoid growth,
type II for fungating growth,
type III for ulcerating growth,
type IV for (...) -
early gastric carcinoma
16 February 2013Early gastric carcinoma is defined as invasive carcinoma confined to mucosa and/or submucosa, with or without lymph node metastases, irrespective of the tumor size.
Most early gastric carcinomas are small, measuring 2 to 5 cm in size, and often located at lesser curvature around angularis. Some early gastric carcinoma can be multifocal, often indicative of a worse prognosis.
Grossly, early gastric carcinoma is divided into:
Type I for the tumor with protruding growth,
Type II with (...) -
carcinomas of gastric cardia and gastroesophageal junction
16 February 2013Cancers at gastric cardia and gastroesophageal junction (GEJ)
Gastric carcinoma is clinically classified as early or advanced stage to help determine appropriate intervention, and histologically into subtypes based on major morphologic component.
For the classification based on anatomic location, difficulty often arises when the tumor is located at proximal stomach or cardia, especially when the tumor also involves gastroesophageal junction (GEJ).
It is not only because there are shared (...) -
lymph node metastasis from gastric cancer
15 February 2013lymph node metastasis from early gastric cancer
Reference
Incidence of lymph node metastasis from early gastric cancer: estimation with a large number of cases at two large centers. Gotoda T, Yanagisawa A, Sasako M, Ono H, Nakanishi Y, Shimoda T, Kato Y. Gastric Cancer. 2000 Dec;3(4):219-225. PMID: #11984739# -
primary bile reflux gastritis
10 February 2013Bile reflux is one of the primary factors involved in the pathogenesis of gastric mucosal lesions in patients with chronic gastritis.
Foveolar hyperplasia was associated with the severity of bile reflux, suggesting that it is a histological feature of primary BRG in children, while vascular congestion may be a protective factor.
In addition to gastric acid and Helicobacter pylori (HP), bile reflux is one of the primary factors involved in the pathophysiological processes leading to (...)
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