Liver and pancreatobiliary system

• cystic intraductal tumors of pancreatobiliary tract
  26 March

  See also
  cystic intraductal tumors
  pancreatobiliary tract

• pancreatobiliary tract
  24 March

  Pathology
  pancreatobiliary tract cytology
  cystic intraductal tumors of pancreatobiliary tract

• combined hepatocellular-cholangiocarcinoma
  29 December 2018

  Combined hepatocellular-cholangiocarcinoma (CHC) is a rare tumor with poor prognosis, with incidence ranging from 1.0%-4.7% of all primary hepatic tumors. This entity will be soon renamed as hepato-cholangiocarcinoma.
  The known risk factors for hepatocellular carcinoma (HCC) have been implicated for CHC including viral hepatitis and cirrhosis. It is difficult to diagnose this tumor pre-operatively.
  The predominant histologic component within the tumor largely determines the predominant (...)

• cholangitis lenta
  26 March 2018

  Definition: Cholangitis lenta, also known as ductular cholestasis, cholangiolar cholestasis, or subacute nonsuppurative cholangitis, is an uncommon type of cholangitis characterized by ductular reaction with inspissated bile in dilated ductules.
  The finding of cholangitis lenta on liver biopsy is thus frequently associated with sepsis and with a high mortality rate. Therefore, accurate diagnosis of this condition on liver biopsy is imperative as it is an indication that the patient may (...)

• pancreatobiliary tumors
  22 March 2017

  Pancreatobiliary Neoplasms
  Open references
  Update 2017 on Pancreatobiliary Neoplasms. http://www.archivesofpathology.org/doi/pdf/10.5858/arpa.2016-0262-SA?code=coap-site

• intraepithelial neoplasia of pancreatobiliary tract
  19 October 2016

  PTBIN; pancreatobiliary tract INs
  tumoral and flat intraepithelial neoplasia
  Tumoral intraepithelial neoplasia presents as an intraluminal or intraductal, mass-forming, polypoid lesion or a macroscopic, visible, cystic lesion without intracystic papillae.
  Microscopically, tumoral intraepithelial neoplasia shows various proportions of papillary and tubular architecture, often with a mixed pattern, such as papillary, tubular, and papillary-tubular.
  The malignant potential depends on the (...)

• pancreatobiliary phenotype
  19 October 2016

  Immunochemistry
  CK7+
  CK20-
  See also
  pancreatobiliary IPMN
  PanIN / PanINs : pancreatic intraepithelial neoplasia

• molecular pathology of pancreatobiliary cytology
  16 October 2016

  molecular pathology of FNA of the pancreas
  Fine-needle aspiration and bile duct brushing cytology have been traditionally used for early detection of pancreaticobiliary malignancy.
  K-ras (KRAS ) mutation has a high predictive value for malignancy in patients with indeterminate pancreaticobiliary cytology and should be included as an important adjuvant diagnostic marker.
  A negative K-ras mutation result does not rule out malignancy, and K-ras mutation can be detected, although (...)

• bile duct brushing
  16 October 2016

  biliary cytology
  Molecular biology
  LOH study (#17227126#)
  References
  Analysis of loss of heterozygosity in atypical and negative bile duct brushing cytology specimens with malignant outcome: are "false-negative" cytologic findings a representation of morphologically subtle molecular alterations?
  Krishnamurti U, Sasatomi E, Swalsky PA, Finkelstein SD, Ohori NP.
  Arch Pathol Lab Med. 2007 Jan;131(1):74-80.
  PMID: #17227126#
  Beyond cytomorphology: expanding the diagnostic potential (...)

• liver and pancreatobiliary cytology
  20 August 2016

  Practical Tips in Cytology of the Liver and Pancreatobiliary System for the Surgical Pathologist (Martha Bishop Pitman, M.D.)
  1. A liver FNA that produces "dirty necrosis" is metastatic colon cancer until proven otherwise.
  2. Clusters of hepatocytes surrounded by endothelial cells are malignant.
  3. Malignant cells wrapped by endothelial cells are hepatocellular carcinoma
  4. Cell blocks and/or core biopsy with FNA is more accurate than either alone for diagnosis of liver masses.
  5. Bile (...)

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