Pancreas

• HADH-associated hyperinsulinism
  25 January 2010

  3-Hydroxyacyl-coenzyme A dehydrogenase deficiency and hyperinsulinemic hypoglycemia

• HNF4A-associated hyperinsulinism
  25 January 2010

  HNF4A-associated congenital hyperinsulinism; HNF4A-CHI

• KCNJ11-associated hyperinsulinism
  25 January 2010

  K(ATP) channels regulate insulin secretion from pancreatic beta-cells. Loss- and gain-of-function mutations in the genes encoding the Kir6.2 and SUR1 subunits of this channel cause hyperinsulinism of infancy and neonatal diabetes, respectively.
  The ATP-sensitive potassium (K(ATP)) channel controls insulin secretion by coupling glucose metabolism to excitability of the pancreatic beta-cell membrane.
  The channel comprises four subunits each of Kir6.2 and the sulphonylurea receptor (SUR1), (...)

• ABCC8-associated hyperinsulinism
  25 January 2010

  Potassium channels in the plasma membrane of the pancreatic beta cells are critical in maintaining glucose homeostasis by responding to ATP and coupling metabolic changes to insulin secretion. These channels consist of subunits denoted the sulfonylurea receptor SUR1 and the inwardly rectifying ion channel KIR6.2, which are encoded by the genes ABCC8 and KCNJ11, respectively.
  Activating mutations in the subunit genes can result in monogenic diabetes, whereas inactivating mutations are the (...)

• pancreatic intraepithelial neoplasia
  12 June 2009

  PanIN; PanINs; 1998 PO
  Definition: Most common precursor lesions of pancreatic ductal adenocarcinoma are microscopic papillary or flat, non-invasive epithelial neoplasms that are usually < 5 mm and confined to pancreatic ducts. It is composed of columnar to cuboidal cells with variable mucin, and divided into three grades according to degree of cytological and architectural atypia (WHO).
  Other precursor lesions are IPMN ( intraductal papillary mucinous neoplasm ) and MCN ( (...)

• pancreatic intraductal tubulopapillary tumor
  26 May 2009

  Intraductal Tubulopapillary Neoplasms of the Pancreas, pancreatic intraductal tubulopapillary tumors, ITPNs

• pancreatic endocrine microadenomatosis
  11 May 2009

  Von Hippel-Lindau disease (VHL) is an inherited syndrome caused by germline mutation in the VHL tumor suppressor gene predisposing to pancreatic endocrine tumors (PET).
  Whether these tumors derive from preexisting endocrine microadenomatosis as in multiple endocrine neoplasia type 1 (MEN1) is yet unknown.
  pVHL regulates hypoxia-inducible factor (HIF) that causes transcription activity of target genes like carbonic anhydrase 9 (CA9), vascular endothelial growth factor (VEGF), and cyclin (...)

• intraductal papillary mucinous neoplasm
  16 October 2008

  pancreatic intraductal papillary mucinous tumors; intraductal papillary mucinous neoplasms of the pancreas; IPMNs; IPMN PO
  Definition: Intraductal grossly visible (1 cm or more) epithelial neoplasm of mucin producing cells, arising in main pancreatic duct or its branches.
  Images
  Macroscopy : IPMN https://twitter.com/GeronimoJrLapac/status/856424085441699840 https://twitter.com/BeynonMD/status/833411358821597188 https://twitter.com/PancPathologist/status/836582726014799874 (...)

• pancreatic ductal adenocarcinoma
  15 October 2008

  PDCAC; pancreatic ductal cancer; pancreatic ductal carcinoma
  Definition: Pancreatic ductal adenocarcinoma is a highly aggressive, lethal human malignancy that continues to elude successful treatment. Although most patients present with metastatic disease, the molecular pathways that underlie tumor progression and metastases are poorly understood.
  Images
  FNA of PDAC
  https://twitter.com/marthabpitman/status/745652503660879874
  https://twitter.com/marthabpitman/status/746029442678530048 (...)

• pancreatic mucinous cystadenoma
  2 October 2008

  Mucinous cystadenoma of the pancreas

0 | ... | 50 | 60 | 70 | 80 | 90 | 100 | 110 | 120 | 130 | ... | 160