Home > E. Pathology by systems > Cardiovascular system > Heart > atrial myxoma
atrial myxoma
Friday 13 January 2006
atrial myxoma
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Images
- https://twitter.com/Haneen_Maghrabi/status/728186924452749312
- https://twitter.com/HRTTRNSPLNTMD/status/782966195116924928
Digital cases
JRC:389 : atrial myxoma.
JRC:14722 : atrial myxoma.
JRC:14792 : atrial myxoma.
JRC:18351 : atrial myxoma.
JRC:18352 : atrial myxoma.
JRC:18344 : atrial myxoma.
JRC:19084 : atrial myxoma.
JRC:19197 : atrial myxoma.
Microscopy
Complex structures resembling cords, nests, rings or poorly formed glands, often surrounding blood vessels
Composed of stellate or globular myxoma cells with abundant eosinophilic cytoplasm, indistinct cell borders, oval nucleus with open chromatin and indistinct nuclei
Abundant mucopolysaccharide (myxoid) ground substance containing chondroitin sulfate and hyaluronic acid (Life Sci 2003;73:849)
Usually inflammation, hemorrhage
Often more cellular and mitotic activity near surface
Variable fibrosis (41%),
calcification (20%),
Gamna-Gandy bodies (17%, identical to those in spleen of sickle cell anemia patients),
ossification (8%),
extramedullary hematopoiesis (7%, more common in children),
mucin-forming glands (3%, Indian Heart J 2003;55:182),
atypia (3%),
thymic rests (1%)
Differential diagnosis
Left atrial appendage thrombus
Metastatic carcinoma: if myxoma has glandular structures; carcinoma has anaplasia, mitotic activity
Mural myxoid thrombi: no nests, cords or rings, calretinin negative
Myxoid sarcoma
Papillary fibroelastoma: on valve cusps, avascular papillary fronds
Variants
familial recurrent atrial myxoma
See also
cardiac myxoma
cardiac tumors
myxomas and myxoid tumors
atrial tumors