cytotoxic lymphomas
Definition: Lymphomas expressing T-cell intracellular antigen-1 (TIA-1) and/or granzyme B.
The expression of cytotoxic granule-associated proteins has been reported in some T-cell or natural killer (NK)-cell lymphomas of mostly extranodal origin, but rarely of nodal origin except for anaplastic large cell lymphoma (ALCL) and Hodgkin’s disease (HD).
Types
anaplastic lymphoma kinase (ALK)-positive ALCL
- T- or null-cell type with expression of CD30+, epithelial membrane antigen (EMA+), and p80/ALK+, but not CD15 or BCL2. None harbored Epstein-Barr virus (EBV)
peripheral T/NK-cell lymphoma, the nodal high-grade cytotoxic type
- pleomorphic, anaplastic, or centroblastoid morphology
- EBV association or CD56 expression
peripheral T-cell lymphoma (nodal low-grade cytotoxic type)
- +/- lymphoepithelioid pattern (Lennert lymphoma)
cytotoxic Hodgkin-like anaplastic large cell lymphoma (ALCL) and Hodgkin lymphoma
- Hodgkin-like ALCL
- Hodgkin lymphoma
References
Kagami Y, Suzuki R, Taji H, Yatabe Y, Takeuchi T, Maeda S, Kondo E, Kojima M, Motoori T, Mizoguchi Y, Okamoto M, Ohnishi K, Yamabe H, Seto M, Ogura M, Koshikawa T, Takahashi T, Kurita S, Morishima Y, Suchi T, Nakamura S. Nodal cytotoxic lymphoma spectrum: a clinicopathologic study of 66 patients. Am J Surg Pathol. 1999 Oct;23(10):1184-200. PMID: #10524519#