del(6q)

Deletion of the long arm of chromosome 6 (del(6q)) is more frequently described in lymphoid proliferations than in other hematological malignancies.

Regions

 deletions are mainly reported to be terminal, but also interstitial (6q11-14)

Tumors

 acute lymphoblastic leukemia (ALL)

• childhood B-cell acute lymphoblastic leukemia (B-ALL) (5-15%)
• childhood T-cell acute lymphoblastic leukemia (T-ALL) (10-20%)
• adult acute lymphoblastic leukemia

 chronic lymphocytic leukemia (CLL)

• atypical chronic lymphocytic leukemia

 prolymphocytic leukemia
 multiple myeloma (15%)
 non-Hodgkin lymphomas (NHL) (15% cases)

• Burkitt lymphoma

 high frequency of deletions of the long arm of chromosome 6 in testicular lymphoma (16865685)

 various cancers

See also

 tumoral deletions

References

 Array comparative genomic hybridization reveals a very high frequency of deletions of the long arm of chromosome 6 in testicular lymphoma. Bosga-Bouwer AG, Kok K, Booman M, Boven L, van der Vlies P, van den Berg A, van den Berg E, de Jong B, Poppema S, Kluin P. Genes Chromosomes Cancer. 2006 Oct;45(10):976-81. PMID: 16865685