nasal NK-cell lymphoma
Nasal NK-cell lymphoma is a common neoplasm in Asia, Latin America and Mexico. It is worth noting it has has been linked to Epstein-Barr virus with T/NK-cell phenotype, which often displays cellular atypia, an angiocentric growth pattern and necrosis.
Immunochemistry
cytoplasmic CD3+
CD56+ (NK cells)
CD57+ (NK cells)
TIA+
BCL2+
Molecular biology
TCR-rearrangement: germline
Associations
AIDS (#2245397#)
See also
natural killer cell tumors (NK-cell lymphomas)
References
Kwong YL. Natural killer-cell malignancies: diagnosis and treatment. Leukemia. 2005 Sep 22; PMID: #16179910#