molecular pathology

Molecular medicine began with Pauling’s seminal work, which recognized sickle-cell anemia as a molecular disease, and with Ingram’s demonstration of a specific chemical difference between the hemoglobins of normal and sickled human red blood cells.

Part I. Pathology of molecules

1. Pathology of DNA

 DNA mutations
 DNA replication
 DNA repair
 molecular checkpoints
 polyglutamine diseases

2. Pathology of RNA

 transcription and RNA synthesis
 RNA processing, RNA splicing, RNA maturation
 RNA transport
 RNA translation

3. Pathology of proteins

 protein lesions
 protein folding
 protein glycosylation
 anomalies of proteolysis and proteasomal degradation
 amyloidoses
 prion diseases

4. Pathology of other molecules (metabolic diseases)

 lipids
 carbohydrates
 vitamins
 bile
 heme

Part II. Pathology of cell signaling

5. External communication

 cell-matrix signaling
 cell-cell signaling
 soluble factor-cell signaling
 mechanosensitivity
 chemosensitivity

6. Pathology of membrane receptors

 Pathology of receptor tyrosine kinases (RTKs)
 Pathology of receptor serine/threonine kinases

7. Pathology of intracellular signaling by cytoplasmic proteins

 Pathology of Ras GTPases proteins family (ras, raf, rap, rho...)

8. Pathology of transcription factors

 Pathology of NF-kappaB

9. Pathology of signaling pathways

 hg signaling pathway (Hedgehog signaling pathway)
 wnt signaling pathway (Wint signaling pathway)
 wg signaling pathway (Wingless signaling pathway)
 notch signaling pathway
 NF-kappaB signaling pathway
 patched signaling pathway

Part III. Pathology of cellular functions

10 - Growth

 Pathology of cellular growth
 Pathology of cellular cycle
 Pathology of cellular division and mitosis
 Pathology of meiosis

11. Pathology of cellular aging

12. Pathology of apoptosis and cellular death

13. Pathology of endocytosis

14. Pathology of membrane transport

15. Pathology of cellular trafficking

16. Pathology of exocytosis

Part IV. Pathology of molecular structures

17. Pathology of extracellular matrix components (connective tissue disorders)

18. Pathology of basal membranes

19. Pathology of intercellular junctions

 Pathology of GAP junctions (connexins)
 Pathology of desmosomes and hemidesmosomes

20. Pathology of the cytoplasmic membrane

21. Pathology of endoplasmic reticulum and Golgi apparatus

22. Pathology of vesicles and membranes

23. Pathology of cytoskeleton

24. Pathology of contractile apparatus

25. Pathology of filopodia

26. Pathology of mitochondria

Part V. Systemic molecular pathology

 Molecular pathology of development

 Molecular pathology of growth (overgrowth syndromes)

 Pathology of aging

 epithelial pathology

Journals

 The Journal of Molecular Diagnostics

 Molecular Pathology from Journal of CLinical Pathology (Mol Pathol)

 Diagnostic Molecular Pathology (Diagn Mol Pathol)

Societies

 Association for Molecular Pathology (AMP)