Clonorchis sinensis
Synopsis
Larvae of C. sinensis reach the biliary system and provoke pathological changes, both as a result of local trauma and of toxic irritation.
The appearances vary with duration and severity of the infestation, but they are sufficiently distinctive and characteristic to allow a classification into four phases as follows:
- 1st phase: desquamation of epithelial cells
- 2nd phase: hyperplasia and desquamation of epithelial cells
- 3rd phase: hyperplasia, desquamation of epithelial cells and adenomatous tissue formation
- 4th phase: marked proliferation of the periductal connective tissue with scattered abortive acini of epithelial cells and fibrosis of the wall of the bile duct
acute stage: chill and fever up to 40 degrees C occur during the acute stage (period less than a month after parasite invasion)
chronic stage (irregular appetite, gastrointestinal disturbances, oedema, hepatomegaly)
cirrhosis with portal hypertension
calculi
acute suppurative cholangitis
recurrent pyogenic cholangitis
cholecystitis
hepatitis
hepatocellular carcinoma
pancreatitis (#8283082#)
- acute pancreatitis
- chronic pancreatitis
- adenocarcinoma of the pancreas
See also
flukes