leucocytic adhesion
Leukocyte adhesion and transmigration are regulated largely by the binding of complementary adhesion molecules on the leukocyte and endothelial surfaces, and chemical mediators-chemoattractants and certain cytokines-affect these processes by modulating the surface expression or avidity of such adhesion molecules.
The adhesion receptors involved belong to four molecular families:
selectins (SELs)
immunoglobulin superfamily (ICAMs)
integrins (ITGs)
mucin-like glycoproteins (like heparan sulfate).
References
Rhee JS, Santoso S, Herrmann M, Bierhaus A, Kanse SM, May AE, Nawroth PP, Colman RW, Preissner KT, Chavakis T. New aspects of integrin-mediated leukocyte adhesion in inflammation: regulation by haemostatic factors and bacterial products. Curr Mol Med. 2003 Jun;3(4):387-92. PMID: #12776993#