situs solitus

Definition: Situs solity is the normality of assymetry or laterality.

Pathology

 heterotaxy (situs anomalies, laterality disorders)

• situs ambiguus (incomplete situs inversus)
• situs inversus totalis
• isomerisms
  • left isomerism
  • right isomerism

 syndromal heterotaxy

• Kartagener syndrome (MIM.244400)
• Ivemark syndrome (aspleny/polyspleny and cardiovascular anomalies) (MIM.208530)
• X-linked visceral heterotaxy (MIM.306955)

References

 Peeters H, Devriendt K. Human laterality disorders. Eur J Med Genet. 2006 Sep-Oct;49(5):349-62. Epub 2006 Jan 3. PMID: 16461029

 Aylsworth AS. Clinical aspects of defects in the determination of laterality. Am J Med Genet. 2001 Jul 15;101(4):345-55. PMID: 11471158

 Casey B. Two rights make a wrong: human left-right malformations. Hum Mol Genet. 1998;7(10):1565-71. PMID: 9735377

 Ibanez-Tallon I, Heintz N, Omran H. To beat or not to beat : roles of cilia in development and disease. Hum Mol Genet. 2003 Apr 2 ;12(Suppl 1) :R27-35. PMID : 12668594

 El Zein L, Omran H, Bouvagnet P. Lateralization defects and ciliary dyskinesia : lessons from algae. Trends Genet. 2003 Mar ;19(3):162-7. PMID : 12615011

See also

 situs anomalies