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familial juvenile systemic granulomatosis

MIM.186580

Dominant disease associating

Synopsis

- systemic granulomatosis

  • cutaneous granulomatosis
    • noncaseating granulomatous skin infiltration
    • ichtyosis
  • granulomatous synovitis
  • cranial basis granulomatosis
    • cranial neuropathies
    • corticosteroid-responsive hearing loss

- nongranulomatous uveitis
- boutonniere deformities
- flexion contractures of fingers and toes
- cysts over wrist and ankle joints
- intermittent generalized erythematous papular rash

Etiology

- germline mutations of the CARD15 (also involved in susceptibility to Crohn disease)

See also

- systemic granulomatoses