robustness

Examples

 developmental robustness

• Morphogen gradients play a pivotal role in most phases of developmental patterning.
• To ensure proper patterning, reproducible gradients are established under diverse environmental conditions and genetic backgrounds.
• Buffer fluctuations in gene dosage or environmental conditions are reffered as ’robustness’.

 robustness in the tissue reconstruction system (TRS) / tissue repair

Open references

 Re-thinking our understanding of immunity: Robustness in the tissue reconstruction system. Truchetet ME, Pradeu T. Semin Immunol. 2018 Apr;36:45-55. doi : 10.1016/j.smim.2018.02.013 PMID: 29550156 Free

References

 Pervasive robustness in biological systems. Félix MA, Barkoulas M. Nat Rev Genet. 2015 Aug;16(8):483-96. doi : 10.1038/nrg3949 PMID: 26184598

 Slepchenko BM, Terasaki M. Bio-switches: what makes them robust? Curr Opin Genet Dev. 2004 Aug;14(4):428-34. PMID: 15261660

 Kerszberg M. Noise, delays, robustness, canalization and all that. Curr Opin Genet Dev. 2004 Aug;14(4):440-5. PMID: 15261662

 Eldar A, Shilo BZ, Barkai N. Elucidating mechanisms underlying robustness of morphogen gradients. Curr Opin Genet Dev. 2004 Aug;14(4):435-9. PMID: 15261661

 Kerszberg M. Noise, delays, robustness, canalization and all that. Curr Opin Genet Dev. 2004 Aug;14(4):440-5. PMID: 15261662

 Eldar A, Shilo BZ, Barkai N. Elucidating mechanisms underlying robustness of morphogen gradients. Curr Opin Genet Dev. 2004 Aug;14(4):435-9. PMID: 15261661

 Tabata T. Genetics of morphogen gradients. Nat Rev Genet. 2001 Aug;2(8):620-30. PMID: 11483986