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Paneth cells
Friday 27 June 2003
Paneth’s cells
Pathology
Paneth cell hyperplasia
Paneth cell carcinoma
Paneth cell differentiation in colonic epithelial tumors
- Paneth cell differentiation may occur in colonic epithelial neoplasms.
- Paneth cell differentiation is common in early colonic neoplasms that develop via the conventional adenoma-carcinoma carcinogenic pathway.
- Activation of Apc/beta-catenin/Tcf pathway may play a role in Paneth cell differentiation in human colonic neoplasms.
- Some studies have linked appearance of Paneth cells in colorectal adenomas to adenoma burden and male gender.
- Synchronous CRC are not associated with Paneth cell status, or a history of AA or CRC.
- Paneth cell presence in the adenomas of distal colorectum may be a negative indicator for synchronous AA and CRC, and seems to warrant further studies.
Paneth Cell-Like Component in Prostate Cancer
See also
cells
Paywall references
Paneth cell differentiation in colonic epithelial neoplasms: evidence for the role of the Apc/beta-catenin/Tcf pathway. Joo M, Shahsafaei A, Odze RD. Hum Pathol. 2009 Jun;40(6):872-80. doi : 10.1016/j.humpath.2008.12.003 PMID: 19269007
Paneth Cell in Adenomas of the Distal Colorectum Is Inversely Associated with Synchronous Advanced Adenoma and Carcinoma. 2016.
https://www.nature.com/articles/srep26129