Actin related proteins located on the cytoskelton (cytoskeletal ARPs) or in the nucleus (nuclear ARPs).
Lamellipodial protrusion
The protrusion of the cell membrane is fundamental to cell shape change and locomotion. Actin polymerization plays a critical role in this process. The leading edge of motile cells is dominated by thin actin-rich structures called lamellipodia, which exhibit highly dynamic behavior characterized by rapid extension and retraction.
Many aspects of the mechanism of lamellipodial protrusion are echoed in the intracellular motility of certain bacterial and viral pathogens, such as the bacterium Listeria monocytogenes.
The Arp2/3 complex contains actin-related proteins (ARPs) in the Arp2 and Arp3 families.
Components
| ACTR1 | ||||
| ARP2 | ARP3 | |||
| ARPC1B | ARPC2 | ARPC3 | ARPC4 | ARPC5 |
See also
References
Blessing CA, Ugrinova GT, Goodson HV. Actin and ARPs: action in the nucleus. Trends Cell Biol. 2004 Aug;14(8):435-42. PMID: 15308210
