Home > E. Pathology by systems > Skin > desmoplastic trichoepithelioma
desmoplastic trichoepithelioma
Wednesday 5 May 2004
Synopsis
cords/nests basaloid cells
sclerotic stroma
horn cysts with keratin
Images
Desmoplastic trichoepithelioma
- https://twitter.com/mariaramir/status/714933005920378882
- https://twitter.com/nathan_t_harvey/status/816954835962576896
Differential diagnosis
cutaneous slerodermiform basal cell carcinoma
microcystic adnexal carcinoma (MAC)
syringoma
Synopsis
Combination of microcysts and thin strands of basaloid epithelium wrapped by collagen
Microcysts
Foci of calcification (calcifeid keratin)
Small strands of epithelium occasionally wrapped by small collagen fibers.
The epithelial component resembles the mantle portion of the follicle.
Other follicular constituents may be present.
Possible clusters of ghost cells (as in pilomatricoma)
Possible clusters of basaloid cells with fibroblastic stroma
Differential diagnosis
sclerosing epithelial neoplasms
- morpheiform basal cell carcinoma
- syringoma
- microcystic adnexal carcinoma
- desmoplastic basal cell carcinoma
- microcystic adnexal carcinoma
ghost cell cutaneous tumors
- pilomatricoma
See also
cutaneous follicular tumors
desmoplastic lesions
- desmoplasia
- desmoplastic anomalies
- desmoplastic tumors
Open References
A case of desmoplastic trichoepithelioma with ossification. Wada M, Hanada K, Kanehisa F, Asai J, Takenaka H, Katoh N. Indian J Dermatol. 2013 Mar;58(2):164. doi : 10.4103/0019-5154.108112 PMID: 23716857 [Free]
Diagnostic utility of immunohistochemistry in distinguishing trichoepithelioma and basal cell carcinoma: evaluation using tissue microarray samples. Tebcherani AJ, de Andrade HF Jr, Sotto MN. Mod Pathol. 2012 Oct;25(10):1345-53. doi : 10.1038/modpathol.2012.96 PMID: 22684216 [Free]
Differentiation between basal cell carcinoma and trichoepithelioma by immunohistochemical staining of the androgen receptor: an overview. Arits AH, Van Marion AM, Lohman BG, Thissen MR, Steijlen PM, Nelemans PJ, Kelleners-Smeets NW. Eur J Dermatol. 2011 Nov-Dec;21(6):870-3. doi : 10.1684/ejd.2011.1504 PMID: 21865121 [Free]