multiple familial trichoepithelioma

Multiple familial trichoepithelioma (MFT) is an autosomal dominant disorder of skin appendage tumors characterized by the appearance of trichoepitheliomas.

 MFT1

• Multiple familial trichoepithelioma-1 (MFT1) is caused by heterozygous mutation in the CYLD gene (MIM.605018) on chromosome 16q12.
• Allelic disorders with overlapping features include familial cylindromatosis (MIM.132700) and Brooke-Spiegler syndrome (BRSS; MIM.605041).

 MFT2 (MIM.612099) has been mapped to 9p21.

See also

 trichoepithelioma