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BerEP4
Friday 20 January 2017
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Definition: BerEP4 : monoclonal antibody againt EPCAM It is an antibody to EpCAM (epithelial cell adhesion molecule).
Images
membranous BerEp4 expression in normal apocrine glands.
Diagnostic use
Membranous staining
basal cell carcinoma (BCC)
- BerEp4 is a histologic stain mainly used to aid in the diagnosis of basal cell carcinoma (BCC).
pulmonary adenocarcinoma
- Sensitive and specific for lung adenocarcinoma (positive) vs. mesothelioma (negative) (, Am J Surg Pathol 2001;25:43)
hepatocellular carcinoma vs cholangiocarcinoma
- May help distinguish, as part of a panel, hepatocellular carcinoma (usually negative) from metastatic adenocarcinoma to liver or cholangiocarcinoma (usually positive, Mod Pathol 2002;15:1279)
Prognostic use
Immunoexpression may predict poor survival in carcinomas of breast, gallbladder (Am J Clin Pathol 2008;129:424), ovary, pancreas
Open references
Use of Ber-EP4 and Epithelial Specific Antigen to Differentiate Clinical Simulators of Basal Cell Carcinoma. Dasgeb B, Mohammadi TM, Mehregan DR. Biomark Cancer. 2013 Jun 25;5:7-11. doi : 10.4137/BIC.S11856 PMID: 24179394 Free
The immunohistochemical differential diagnosis of microcystic adnexal carcinoma, desmoplastic trichoepithelioma and morpheaform basal cell carcinoma using BerEP4 and stem cell markers. Sellheyer K, Nelson P, Kutzner H, Patel RM. J Cutan Pathol. 2013 Apr;40(4):363-70. doi : 10.1111/cup.12085 PMID: 23398472 Free
Caveats in BerEP4 staining to differentiate basal and squamous cell carcinoma.
Yu L, Galan A, McNiff JM. J Cutan Pathol. 2009 Oct;36(10):1074-176. doi : 10.1111/j.1600-0560.2008.01223.x PMID: 19187107 Free