penile intraepithelial neoplasia

Image

 penile intraepithelial neoplasia and SCC

• https://twitter.com/AdamGomezMD/status/737297866125803520

Penile intraepithelial neoplasia (PeIN ) has been coined to encompass the three preinvasive clinical entities of:

 penile Bowen disease
 erythroplasia of Queyrat
 bowenoid papulosis.

Synopsis

 Differentiated PeIN

• Thickened epithelium with hyperkeratosis, parakeratosis, and
  hypergranulosis
• Elongated and anastomosing rete ridges
• Subtle abnormal maturation (enlarged keratinocytes with
  abundant eosinophilic cytoplasm )
• Keratin pearl formation
• Prominent intercellular bridges (lack of cohesion )
• Dysplastic hyperchromatic basal cells

 Basaloid PeIN

• Epithelium replaced by a monotonous population of small to
  intermediate size blue cells with a high nuclear/cytoplasmic
  ratio
• Parakeratosis with a flat surface
• Abundant mitotic figures and apoptosis
• Isolated koilocytes in the superficial layers

 Warty PeIN

• Thickened epithelium with an undulating and spiking surface
  and striking cellular pleomorphism
• Atypical parakeratosis and dyskeratosis
• Conspicuous koilocytosis (hyperchromatic wrinkled nuclei ,
  perinuclear halos , multinucleation )
• Abundant mitoses

See also

 penile anomalies
 intraepithelial neoplasia (INs or IN )

See also

 penile tumors

• penile carcinomas