crystals in lymph node

Types

 calcifications

• spherulitic calcification
• smooth calcification
• crystallized apatite
• whitlockite
  • isolated and well-crystallized whitlockite

 cholesterol crystals

 sarcoisosis
 Rosai-Dorfman disease (16121057)

• Skin lesions can show classic features of cutaneous RDD with the additional feature of conspicuous rhomboidal and needle-shaped crystals within the cytoplasm of many lesional plasma cells, histiocytes, and also in an extra-cellular location. (16121057)

 drugs

• clofazimine (15282969)

 silicosis

• supraclavicular lymph node (10201057)
• nodules with bi-refringent crystals (10201057)

 lymphoplasmocytic proliferation

• multiple myeloma-associated Fanconi disease (2500924)

To-do

 polarization for birefringence

References

 Crystals and calcification patterns in two lymph node calcifications. Sakae T, Yamamoto H. J Oral Pathol. 1987 Oct;16(9):456-62. PMID: 3123624

 A case report of anthracosilicotic spindle-cell pseudotumor of mediastinal lymph node: cytologic diagnosis by endoscopic ultrasound-guided fine-needle aspiration. Varghese LR, Stanley MW, Wakely PE Jr, Lucido ML, Mallery S, Bardales RH. Diagn Cytopathol. 2005 Oct;33(4):268-72. PMID: 16138379

 Crystal deposition in a case of cutaneous Rosai-Dorfman disease. Motta L, McMenamin ME, Thomas MA, Calonje E. Am J Dermatopathol. 2005 Aug;27(4):339-42. PMID: 16121057

 Intra-abdominal, crystal-storing histiocytosis due to clofazimine in a patient with lepromatous leprosy and concurrent carcinoma of the colon. Pais AV, Pereira S, Garg I, Stephen J, Antony M, Inchara YK. Lepr Rev. 2004 Jun;75(2):171-6. PMID: 15282969

 Cytoplasmic crystals in multiple myeloma-associated Fanconi’s syndrome. A morphological study including immunoelectron microscopy. Truong LD, Mawad J, Cagle P, Mattioli C. Arch Pathol Lab Med. 1989 Jul;113(7):781-5. PMID: 2500924