CD117

Voir KIT

Positive staining in normal cells

Interstitial cells of Cajal
hematopoietic progenitor cells
melanocytes
embryonic/fetal brain
endothelium
gonads
mast cells
breast epithelium
germ cells

Positive staining in tumors
AML
angiomyolipoma
angiosarcomas
clear cell sarcoma
CML
epithelioid sarcoma
Ewing sarcoma
gastrointestinal autonomic tumor (GANT)
gastrointestinal stromal tumor (GIST)
granulocytic sarcoma
Hodgkin lymphoma (some Reed-Sternberg cells)
intraabdominal fibromatosis
mast cell disease
melanoma
mesenteric fibromatosis
mental mesenchymal tumor
osteosarcomaa
rhabdomyosarcoma
sclerosing mesenteritis (variable)
seminomas / dysgerminomas
small cell lung cancer
synovial sarcoma ( 10%, usually cytoplasmic staining)
adenoid cystic carcinoma of salivary gland (strong staining)

Negative staining
Alveolar soft part sarcoma
desmoplastic small round cell tumor
glomus tumor, leiomyoma (retroperitoneal, colorectal)
leiomyosarcoma
myxoma (cardiac)
schwannoma (colorectal)
smooth muscle tumor of uncertain malignant potential
solitary fibrous tumor