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mycophenolate-associated colitis
Monday 14 October 2013
Mycophenolate mofetil (MMF) is a T-cell inhibitor frequently used in the treatment of acute allograft rejection. MMF may cause colitis that clinically and histologically resembles graft-versus-host disease (GVHD).
A variety of histologic features, in particular, eosinophils >15 per 10 HPF, lack of endocrine cell aggregates in the lamina propria, and lack of apoptotic microabscesses, can be used by pathologists to help separate MMF from GVHD-induced colitis in routine clinical practice.
Differential diagnosis
GVHD-induced colitis (24076772)
Reference
Histologic Features in Colon Biopsies Can Discriminate Mycophenolate From GVHD-induced Colitis. Star KV, Ho VT, Wang HH, Odze RD. Am J Surg Pathol. 2013 Sep;37(9):1319-28. doi : 10.1097/PAS.0b013e31829ab1ef PMID: 24076772