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MUC6
Friday 23 March 2012
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MUC6 expression in pyloric gland adenoma
Synopsis
Produces protective glycoprotein coat for gut epithelia
Positive staining - normal: stomach (pyloric glands), gallbladder, colon and endocervix
Positive staining - disease: invasive ductal carcinoma of breast, gastric carcinomas
Negative staining: normal breast tissue
References
Divergent Expression of MUC5AC, MUC6, MUC2, CD10, and CDX-2 in Dysplasia and Intramucosal Adenocarcinomas With Intestinal and Foveolar Morphology: Is This Evidence of Distinct Gastric and Intestinal Pathways to Carcinogenesis in Barrett Esophagus? Khor TS, Alfaro EE, Ooi EM, Li Y, Srivastava A, Fujita H, Park Y, Kumarasinghe MP, Lauwers GY. Am J Surg Pathol. 2012 Mar;36(3):331-342. PMID: 22261707