NUT

The deduced 1,127-amino acid protein coded by NUT has a calculated molecular mass of about 120 kD. Northern blot analysis of several normal human tissues detected a 3.6-kb transcript only in testis.

Expression in tumors

 NUT in not expressed in primary lung tumours. (26341600)

Pathology

 NUT-associated midline carcinoma
 NUT-associated pulmonary carcinoma

• Nota bene: NUT is not expressed in usual primary lung tumours (26341600)

Open References

 NUT expression in primary lung tumours. Lund-Iversen M, Grøholt KK, Helland Å, Borgen E, Brustugun OT. Diagn Pathol. 2015 Sep 5;10(1):156. doi : 10.1186/s13000-015-0395-9 PMID: 26341600 (Free)

References

 The cytologic features of NUT midline carcinoma. Bellizzi AM, Bruzzi C, French CA, Stelow EB. Cancer Cytopathol. 2009 Sep 30. PMID: 19795508

 NUT midline carcinoma of the parotid gland with mesenchymal differentiation. den Bakker MA, Beverloo BH, van den Heuvel-Eibrink MM, Meeuwis CA, Tan LM, Johnson LA, French CA, van Leenders GJ. Am J Surg Pathol. 2009 Aug;33(8):1253-8. PMID: 19561446

 Carcinomas of the upper aerodigestive tract with rearrangement of the nuclear protein of the testis (NUT) gene (NUT midline carcinomas). Stelow EB, French CA. Adv Anat Pathol. 2009 Mar;16(2):92-6. PMID: 19550370

 Diagnosis of NUT Midline Carcinoma Using a NUT-specific Monoclonal Antibody. Haack H, Johnson LA, Fry CJ, Crosby K, Polakiewicz RD, Stelow EB, Hong SM, Schwartz BE, Cameron MJ, Rubin MA, Chang MC, Aster JC, French CA. Am J Surg Pathol. 2009 Jul;33(7):984-91. PMID: 19363441

 Molecular pathology of NUT midline carcinomas. French CA. J Clin Pathol. 2008 Jun 13. PMID: 18552174

 NUT rearrangement in undifferentiated carcinomas of the upper aerodigestive tract. Stelow EB, Bellizzi AM, Taneja K, Mills SE, Legallo RD, Kutok JL, Aster JC, French CA. Am J Surg Pathol. 2008 Jun;32(6):828-34. PMID: 18391746

 BRD-NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells. French CA, Ramirez CL, Kolmakova J, Hickman TT, Cameron MJ, Thyne ME, Kutok JL, Toretsky JA, Tadavarthy AK, Kees UR, Fletcher JA, Aster JC. Oncogene. 2008 Apr 3;27(15):2237-42. PMID: 17934517

 Recurrent fusion oncogenes in carcinomas. Teixeira MR. Crit Rev Oncog. 2006 Dec;12(3-4):257-71. PMID: 17425505

 Midline carcinoma with t(15;19) and BRD4-NUT fusion oncogene in a 30-year-old female with response to docetaxel and radiotherapy. Engleson J, Soller M, Panagopoulos I, Dahlén A, Dictor M, Jerkeman M. BMC Cancer. 2006 Mar 16;6:69. PMID: 16542442

 Midline carcinoma of children and young adults with NUT rearrangement. French CA, Kutok JL, Faquin WC, Toretsky JA, Antonescu CR, Griffin CA, Nose V, Vargas SO, Moschovi M, Tzortzatou-Stathopoulou F, Miyoshi I, Perez-Atayde AR, Aster JC, Fletcher JA. J Clin Oncol. 2004 Oct 15;22(20):4135-9. PMID: 15483023

 BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. French CA, Miyoshi I, Kubonishi I, Grier HE, Perez-Atayde AR, Fletcher JA. Cancer Res. 2003 Jan 15;63(2):304-7. PMID: 12543779