hairy cell leukemia
Cytogenetics
Overrepresentation of chromosome 5 represents a recurrent aberration in HCL and that the commonly overrepresented region resides in 5q13-q31.
Chromosomal imbalances including deletions of the tumor suppressor gene loci 9p21/P16(INK4A), 13q14/D13S25, and 17p13/P53 rarely occur in HCL in contrast to some other subtypes of B-cell NHL. (#11463458#)
References
Chromosomal gains and losses are uncommon in hairy cell leukemia: a study based on comparative genomic hybridization and interphase fluorescence in situ hybridization. Dierlamm J, Stefanova M, Wlodarska I, Michaux L, Hinz K, Penas EM, Maes B, Hagemeijer A, De Wolf-Peeters C, Hossfeld DK. Cancer Genet Cytogenet. 2001 Jul 15;128(2):164-7. PMID: #11463458#