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near-tetraploidy
Monday 17 September 2007
Tumors
childhood acute lymphoblastic leukemia (ALL)
- Near-tetraploidy (82-94 chromosomes) makes up fewer than 1% of childhood acute lymphoblastic leukemia (ALL) cases and has been reportedly associated with a possibly poorer prognosis compared with other ploidy groups.
- Near-tetraploidy is a specific feature of ETV6/RUNX1+ BCP ALL (16552772).
References
Attarbaschi A, Mann G, Konig M, Steiner M, Dworzak MN, Gadner H, Haas OA; Austrian Berlin-Frankfurt-Munster Cooperative Study Group. Near-tetraploidy in childhood B-cell precursor acute lymphoblastic leukemia is a highly specific feature of ETV6/RUNX1-positive leukemic cases. Genes Chromosomes Cancer. 2006 Jun;45(6):608-11. PMID: 16552772