MYO5A
Unconventional myosins of several classes as MYO5A have been implicated as cytoskeletal proteins involved in actin-dependent movement of organelles and membrane transport in a variety of organisms.
Animal model
Studies of mice lacking myosin-Va have indicated that it is involved in distributing melanosomes to the cell periphery and in the local movement or processing of organelles in specific regions of neurites.
This finding sheds light on the cause of the pigmentary dilution and the neurologic symptoms associated with the disease in humans.
Pathology
Griscelli syndrome (12058346)
Elejalde syndrome (12058346)
The similarity of the phenotypes of Griscelli disease and the Chediak-Higashi disease indicates that the products of the genes encoding myosin-Va (MYO5A) and lysosomal-trafficking regulator may interact physically or function in the same intracellular transport pathways responsible for the normal dynamics of lysosome-related organelles.
See also
References
Sellers JR, Veigel C. Walking with Myosin v. Curr Opin Cell Biol. 2006 Feb;18(1):68-73. Epub 2005 Dec 27. PMID: 16378722
Stinchcombe J, Bossi G, Griffiths GM. Linking albinism and immunity: the secrets of secretory lysosomes. Science. 2004 Jul 2;305(5680):55-9. PMID: 15232098
Tyska MJ, Mooseker MS. Myosin-V motility: these levers were made for walking. Trends Cell Biol. 2003 Sep;13(9):447-51. PMID: 12946621