CAMTA1

Definition: CAMTA1 (calmodulin-binding transcription activator 1) gene spans a minimal region of 1p36 loss in gliomas with oligodendrial differentiation but is not subject to somatic mutations. CAMTA1 expression is cell cycle dependent, being higher in the S and M phases. CAMTA1 is a putative 1p36 cancer gene.

Pathology

 A WWTR1-CAMTA1 gene fusion is a consistent abnormality in epithelioid hemangioendothelioma of different anatomic sites. (21584898)

• Epithelioid hemangioendothelioma (EHE) is a malignant endothelial neoplasm characterized by recurrent translocations involving chromosomal regions 1p36.3 and 3q25, resulting in the formation of a WWTR1-CAMTA1 fusion gene in approximately 90% of cases.
• A small subset (@<@5%) have a YAP1-TFE3 fusion gene.

 Hemizygous deletion of chromosome 1p is common in many cancers, including many oligodendrogliomas (where it is a favorable prognostic marker) and neuroblastomas (NB) (where it is a negative prognostic marker), and some Ewing sarcomas (EWS).

Use in diagnosis

 Nuclear Expression of CAMTA1 Distinguishes Epithelioid Hemangioendothelioma From Histologic Mimics. (26414223)

See also

 1p36 LOH

References

 Nuclear Expression of CAMTA1 Distinguishes Epithelioid Hemangioendothelioma From Histologic Mimics. Doyle LA, Fletcher CD, Hornick JL. Am J Surg Pathol. 2016 Jan;40(1):94-102. doi : 10.1097/PAS.0000000000000511 PMID: 26414223

 CAMTA1 is a useful immunohistochemical marker for diagnosing epithelioid haemangioendothelioma. Ryo Shibuya, Atsuji Matsuyama*, Eisuke Shiba, Hiroshi Harada, Kei Yabuki andMasanori Hisaoka. 22 MAY 2015. http://onlinelibrary.wiley.com/doi/10.1111/his.12713/abstract

 A novel WWTR1-CAMTA1 gene fusion is a consistent abnormality in epithelioid hemangioendothelioma of different anatomic sites. Errani C, Zhang L, Sung YS, Hajdu M, Singer S, Maki RG, Healey JH, Antonescu CR. Genes Chromosomes Cancer. 2011 Aug;50(8):644-53. PMID: 21584898

 Huentelman MJ, Papassotiropoulos A, Craig DW, Hoerndli FJ, Pearson JV, Huynh KD, Corneveaux J, Hanggi J, Mondadori CR, Buchmann A, Reiman EM, Henke K, de Quervain DJ, Stephan DA. Calmodulin-binding transcription activator 1 (CAMTA1) alleles predispose human episodic memory performance. Hum Mol Genet. 2007 Apr 30; PMID: 17470457

 Henrich KO, Claas A, Praml C, Benner A, Mollenhauer J, Poustka A, Schwab M, Westermann F. Allelic variants of CAMTA1 and FLJ10737 within a commonly deleted region at 1p36 in neuroblastoma. Eur J Cancer. 2007 Feb;43(3):607-16. PMID: 17222547

 Kim MY, Yim SH, Kwon MS, Kim TM, Shin SH, Kang HM, Lee C, Chung YJ. Recurrent genomic alterations with impact on survival in colorectal cancer identified by genome-wide array comparative genomic hybridization. Gastroenterology. 2006 Dec;131(6):1913-24. PMID: 17087931

 Henrich KO, Fischer M, Mertens D, Benner A, Wiedemeyer R, Brors B, Oberthuer A, Berthold F, Wei JS, Khan J, Schwab M, Westermann F. Reduced expression of CAMTA1 correlates with adverse outcome in neuroblastoma patients. Clin Cancer Res. 2006 Jan 1;12(1):131-8. PMID: 16397034

 Barbashina V, Salazar P, Holland EC, Rosenblum MK, Ladanyi M. Allelic losses at 1p36 and 19q13 in gliomas: correlation with histologic classification, definition of a 150-kb minimal deleted region on 1p36, and evaluation of CAMTA1 as a candidate tumor suppressor gene. Clin Cancer Res. 2005 Feb 1;11(3):1119-28. PMID: 15709179

 Nakatani K, Nishioka J, Itakura T, Nakanishi Y, Horinouchi J, Abe Y, Wada H, Nobori T. Cell cycle-dependent transcriptional regulation of calmodulin-binding transcription activator 1 in neuroblastoma cells. Int J Oncol. 2004 Jun;24(6):1407-12. PMID: 15138581

 Katoh M, Katoh M. Identification and characterization of FLJ10737 and CAMTA1 genes on the commonly deleted region of neuroblastoma at human chromosome 1p36.31-p36.23. Int J Oncol. 2003 Oct;23(4):1219-24. PMID: 12964007