Mutation testing by genes

EGFR testing; EGFR mutation testing
References
A Multicenter Blinded Study Evaluating EGFR and KRAS Mutation Testing Methods in the Clinical Non-Small Cell Lung Cancer Setting-IFCT/ERMETIC2 Project Part 1: Comparison of Testing Methods in 20 French Molecular Genetic National Cancer Institute Platforms. Beau-Faller M, Blons H, Domerg C, Gajda D, Richard N, Escande F, Solassol J, Denis MG, Cayre A, Nanni-Metellus I, Olschwang S, Lizard S, Piard F, Pretet JL, de Fraipont F, Bièche I, de (...)

References
Comparison of FISH, PCR, and immunohistochemistry in assessing EGFR status in lung adenocarcinoma and correlation with clinicopathologic features. El-Zammar OA, Zhang S, Katzenstein AL. Diagn Mol Pathol. 2009 Sep;18(3):133-7. PMID: #19704257#
EGFR assays in lung cancer. Dacic S. Adv Anat Pathol. 2008 Jul;15(4):241-7. PMID: #18580100#

Microsatellite instability testing, MSI testing in clinics

KRAS mutation detection; RAS testing
Definition: Colorectal cancer is ranked the third most common cancer worldwide in terms of incidence and the second in terms of mortality.
Recent advances in therapeutic approaches to colorectal cancer have identified a potential role of anti-epidermal growth factor receptor (EGFR) targeted therapies as adjuvant treatment in advanced disease.
New evidences showed that patients harboring KRAS mutations on codons 12 and 13 are not responsive to (...)