Nervous system

• Pelizaeus-Merzbacher-like disease
  15 June 2004

  Etiology
  mutations of GJA12 in the Pelizaeus-Merzbacher-like disease (#15192806#)
  Features
  hypomyelinating leukodystrophies

• hypomyelinating leukodystrophies
  15 June 2004

  Hypomyelinating leukodystrophies (HMLs) are disorders involving aberrant myelin formation.
  The prototype of primary HMLs is the X-linked Pelizaeus-Merzbacher disease (PMD) caused by mutations in PLP1.
  Homozygous mutations in GJA12 encoding connexin 47 were found in patients with autosomal-recessive Pelizaeus-Merzbacher-like disease (PMLD).
  Exemples
  X-linked Pelizaeus-Merzbacher disease (PLP1 mutations)
  autosomal-recessive Pelizaeus-Merzbacher-like disease (PMLD) (GJA12)
  References (...)

• giant axonal neuropathy
  18 March 2004

  References
  Mahadevan A, Santosh V, Gayatri N, Ratnavalli E, NandaGopal R, Vasanth A, Roy AK, Shankar SK. Infantile neuroaxonal dystrophy and giant axonal neuropathy—overlap diseases of neuronal cytoskeletal elements in childhood? Clin Neuropathol. 2000 Sep-Oct;19(5):221-9. PMID: #11048747#
  Ouvrier RA. Giant axonal neuropathy. A review. Brain Dev. 1989;11(4):207-14. PMID: (...)

• synapse
  4 December 2003

  synapses; synaptic junction WKP
  See also
  synaptogenesis
  References
  Takeichi M, Abe K. Synaptic contact dynamics controlled by cadherin and catenins. Trends Cell Biol. 2005 Apr;15(4):216-21. PMID: #15817378#
  Kim E, Sheng M. PDZ domain proteins of synapses. Nat Rev Neurosci. 2004 Oct;5(10):771-81. PMID: #15378037#
  Matteoli M, Coco S, Schenk U, Verderio C. Vesicle turnover in developing neurons: how to build a presynaptic terminal. Trends Cell Biol. 2004 Mar;14(3):133-40. PMID: (...)

• synaptic plasticity
  4 December 2003

  References
  Turrigiano GG. More than a sidekick: glia and homeostatic synaptic plasticity. Trends Mol Med. 2006 Oct;12(10):458-60. PMID: #16931159#
  Collingridge GL, Isaac JT, Wang YT. Receptor trafficking and synaptic plasticity. Nat Rev Neurosci. 2004 Dec;5(12):952-62. PMID: #15550950#
  Blitz DM, Foster KA, Regehr WG. Short-term synaptic plasticity: a comparison of two synapses. Nat Rev Neurosci. 2004 Aug;5(8):630-40. PMID: #15263893#
  Winder DG, Egli RE, Schramm NL, Matthews RT. (...)

• axons
  2 December 2003

  See also
  axonal guidance
  axonal transport
  References
  Baas PW, Ahmad FJ. Force generation by cytoskeletal motor proteins as a regulator of axonal elongation and retraction. Trends Cell Biol. 2001 Jun;11(6):244-9. PMID: #11356360#

• mechanosensation
  2 December 2003

  mechanotransduction

• Neuroblasts
  25 November 2003

  asymmetric division
  In the embryonic central nervous system of the fruit fly Drosophila, most neurons and glial cells are generated by asymmetric division of neural stem cells called neuroblasts.
  Several genes have been identified that are required for the establishment of neuroblast polarity, for the asymmetric segregation of cell fate determinants and for the proper orientation and geometry of the mitotic spindle.
  See also
  tumoral neuoblasts immature neuroblasts differentiating (...)

• neuronal connectivity
  24 November 2003

  synaptic plasticity

• myelin disorders
  21 November 2003

  References
  Yool DA, Edgar JM, Montague P, Malcolm S. The proteolipid protein gene and myelin disorders in man and animal models. Hum Mol Genet. 2000 Apr 12;9(6):987-92. PMID: #10767322#

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