Nervous system

• neurodegeneration
  16 July 2003

  Neurodegenerative diseases typically involve deposits of inclusion bodies that contain abnormal aggregated proteins. Therefore, it has been suggested that protein aggregation is pathogenic.
  However, several lines of evidence indicate that inclusion bodies are not the main cause of toxicity, and probably represent a cellular protective response. Aggregation is a complex multi-step process of protein conformational change and accretion.
  The early species in this process might be most toxic, (...)

• neuronal survival
  16 July 2003
• synaptic vesicles
  13 July 2003

  Synaptic vesicles store neurotransmitters that are released during calcium-regulated exocytosis. The specificity of neurotransmitter release requires the localization of both synaptic vesicles and calcium channels to the presynaptic active zone.
  References
  Matteoli M, Coco S, Schenk U, Verderio C. Vesicle turnover in developing neurons: how to build a presynaptic terminal. Trends Cell Biol. 2004 Mar;14(3):133-40. PMID: #15003622#
  Valtorta F, Meldolesi J, Fesce R. Synaptic vesicles: is (...)

• motoneuron
  11 July 2003

  Motoneuron anomalies
  Motoneuron diseases

• neurons
  25 June 2003

  In the CNS, neurons are topographically organized either as aggregates (nuclei, ganglia) or as elongated columns or layers (such as the intermediolateral gray column of the spinal cord or the six-layered cerebral cortex).
  Functional domains are located in many of these anatomically defined regions (such as the hypoglossal nucleus of the medulla for motor fibers of the twelfth cranial nerve; calcarine cortex of the occipital lobe for primary visual cortex).
  In addition, as a further (...)

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