Home > E. Pathology by systems > Nervous system > Neuroblasts
Neuroblasts
Tuesday 25 November 2003
asymmetric division
In the embryonic central nervous system of the fruit fly Drosophila, most neurons and glial cells are generated by asymmetric division of neural stem cells called neuroblasts.
Several genes have been identified that are required for the establishment of neuroblast polarity, for the asymmetric segregation of cell fate determinants and for the proper orientation and geometry of the mitotic spindle.
See also
tumoral neuoblasts
- immature neuroblasts
- differentiating neuroblasts
References
Wodarz A. Molecular control of cell polarity and asymmetric cell division in Drosophila neuroblasts. Curr Opin Cell Biol. 2005 Oct;17(5):475-81. PMID: 16099639
Lin H, Schagat T. Neuroblasts: a model for the asymmetric division of stem cells. Trends Genet. 1997 Jan;13(1):33-9. PMID: 9009846
