Cellular therapy

• hematopoietic stem cell therapy
  17 October 2011

  HSCs Therapy

• mesenchymal stem cell therapy
  17 October 2011

  MSCs therapy

• ASC therapy
  17 October 2011

  Adult stem cells are multipotent cells committed to specific lineages. They can replenish dying cells and damaged tissues by multiplying through cell division and differentiating into a subset of cell types specific to its lineage. As such, they hold vast regenerative and therapeutic potential.
  Furthermore, their use in cell therapy is less controversial as they can be harvested from various sources in humans whereas the use of human embryonic stem cells (hESCs) often entails destruction (...)

• hESC therapy
  17 October 2011

  hESCs therapy

• allogeneic cell therapy
  17 October 2011

  Allogeneic cell therapy involves harvesting donor cells from one, or a few, universal donors. These cells will be expanded in a manufacturing facility and cryopreserved for later manipulation or as therapeutic doses. This allogeneic approach utilizes cell types that do not elicit immune responses upon implantation and therefore have the potential to treat hundreds of patients from a single manufactured lot of cells. The allogeneic methodology fits the pharmaceutical model of drug (...)

• autologous cell therapy
  17 October 2011

  There are two general classes of cell therapy approaches to treat patients.
  First, cells may be harvested from a patient and treated or expanded and introduced back into the same patient. This patient-specific, or autologous, method has historically been favored due to the lack of required immunologic matching.
  A second approach involves the harvesting of cells from one, or a few, universal donors followed by large scale expansion and banking of multiple doses (see "allogeneic cell (...)

• cell therapy
  17 October 2011

  cellular therapy

• splenic stem cells
  29 August 2005

  The spleen of adult mice holds a reservoir of stem cells that can rapidly and robustly differentiate into functional cells of diverse lineages.
  Splenic stem cells express Hox11, a key embryonic transcription factor that regulates organogenesis.
  The presence of multi-lineage stem cells in the spleen might represent lifelong persistence of cells from a primitive embryonic region called the aorta-gonad-mesonephros.
  References
  Kodama S, Davis M, Faustman DL. Regenerative medicine: a (...)

• transdifferentiation
  4 May 2004

  See also
  Metaplasia
  References
  Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration. Jopling C, Boue S, Izpisua Belmonte JC. Nat Rev Mol Cell Biol. 2011 Feb;12(2):79-89. PMID: #21252997#
  Slack JM. Metaplasia and transdifferentiation: from pure biology to the clinic. Nat Rev Mol Cell Biol. 2007 May;8(5):369-78. PMID: #17377526#
  Rodic N, Rutenberg MS, Terada N. Cell fusion and reprogramming: resolving our transdifferences. Trends Mol Med. 2004 (...)

• stem cells > neural tissue
  19 April 2004

  References
  Hess DC, Hill WD, Martin-Studdard A, Carothers J, Brailer J, Carroll J. Blood into brain after stroke. Trends Mol Med. 2002 Sep;8(9):452-3. PMID: #12223318#

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