migraine
Migraine is a complex, disabling disorder of the brain that manifests itself as attacks of often severe, throbbing head pain with sensory sensitivity to light, sound and head movement. There is a clear familial tendency to migraine, which has been well defined in a rare autosomal dominant form of familial hemiplegic migraine (FHM).
FHM mutations so far identified include those in CACNA1A (P/Q voltage-gated Ca(2+) channel), ATP1A2 (N(+)-K(+)-ATPase) and SCN1A (Na(+) channel) genes.
Susceptibility loci
4q21
5q21 (#16080125#)
8q21
10q22-q23 (#18423523#)
14q21
18q12
Xp21
migraine without aura
- 14q21.2-q22.3 (#12474141#)
migraine with aura
- 15q11-q13 (#15586324#)
References
Goadsby PJ. Recent advances in understanding migraine mechanisms, molecules and therapeutics. Trends Mol Med. 2007 Jan;13(1):39-44. PMID: #17141570#
Pietrobon D, Striessnig J. Neurobiology of migraine. Nat Rev Neurosci. 2003 May;4(5):386-98. PMID: #12728266#