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central giant cell granuloma
Tuesday 4 April 2006
CGCG, central giant cell granuloma, giant cell granuloma of the jaws
Definition: Central giant cell granuloma (CGCG) of the jaws is a central osteolytic lesion characterized histologically by multinucleated giant cells in a background of ovoid to spindle-shaped mesenchymal cells. Whether CGCG is a reactive lesion or a truly benign neoplasm remains undetermined, and the mechanism determining the onset of the disease remains unknown.
Localization
maxillary mandible
Expression profiling: 15915104
Gene overexpression
Cyclin D1 protein overexpression (15128059)
See also
giant cell granuloma of the bone
- peripheral giant cell granuloma
References
Liu B, Yu SF, Li TJ. Multinucleated giant cells in various forms of giant cell containing lesions of the jaws express features of osteoclasts. J Oral Pathol Med. 2003 Jul;32(6):367-75. PMID: 12787044