Home > A. Molecular pathology > protein folds
protein folds
Monday 27 February 2006
New protein folds have emerged throughout evolution, but it remains unclear how a protein fold can evolve while maintaining its function, particularly when fold changes require several sequential gene rearrangements.
See also
protein misfoldind protein misfolding diseases protein topologies
References
Peisajovich SG, Rockah L, Tawfik DS. Evolution of new protein topologies through multistep gene rearrangements. Nat Genet. 2006 Feb;38(2):168-74. PMID: 16415885