PI3K/PTEN/AKT signaling pathway
Image Gallery
[ (||image_reduire{0,60}|inserer_attribut{alt,PI3K/Akt signaling}) ] [ (||image_reduire{0,60}|inserer_attribut{alt,PI3K/PTEN/AKT signaling pathway (From Biocarta)}) ] [ (||image_reduire{0,60}|inserer_attribut{alt,Signal-transduction pathway of the TrkA tyrosine kinase receptor.}) ]
Members: AKTs, PTEN
Pathology (Dysregulation of the phosphoinositol-3-kinase/Akt pathway)
PTEN germline mutations and dysregulation of the phosphoinositol-3-kinase/Akt pathway
- Cowden disease
- Bannayan-Riley-Ruvalcaba syndrome
- Lhermitte-Duclos disease
genetic alterations and aberrant expression of genes related to the phosphatidyl-inositol-3’-kinase/protein kinase B (Akt) signal transduction pathway in glioblastoma (#14655756#)
ERBB3 mutations in lethal congenital contractural syndrome type 2 (LCCS2) (#17701904#)
- ERBB3 (Her3) is an activator of the phosphatidylinositol-3-kinase/Akt pathway, regulating cell survival and vesicle trafficking. ERBB3 is essential for the generation of precursors of Schwann cells that normally accompany peripheral axons of motor neurons.
By tumors
neuroblastoma
retinoblastoma (#19420344#)
acute myeloid leukemia (#19951971#)
Se also
TSC/mTOR pathway
Reviews
Role of the PI3K/AKT and mTOR signalling pathways in acute myeloid leukemia. Park S, Chapuis N, Tamburini J, Bardet V, Cornillet-Lefebvre P, Willems L, Green A, Mayeux P, Lacombe C, Bouscary D. Haematologica. 2009 Nov 30. PMID: #19951971#
PI3K/Akt pathway mutations in retinoblastoma. Cohen Y, Merhavi-Shoham E, Avraham-Lubin BC, Savetsky M, Frenkel S, Pe’er J, Goldenberg-Cohen N. Invest Ophthalmol Vis Sci. 2009 Nov;50(11):5054-6. PMID: #19420344#
Hennessy BT, Smith DL, Ram PT, Lu Y, Mills GB. Exploiting the PI3K/AKT pathway for cancer drug discovery. Nat Rev Drug Discov. 2005 Dec;4(12):988-1004. PMID: #16341064#
Parsons DW, Wang TL, Samuels Y, Bardelli A, Cummins JM, DeLong L, Silliman N, Ptak J, Szabo S, Willson JK, Markowitz S, Kinzler KW, Vogelstein B, Lengauer C, Velculescu VE. Colorectal cancer: mutations in a signalling pathway. Nature. 2005 Aug 11;436(7052):792. PMID: #16094359#
Inoki K, Corradetti MN, Guan KL. Dysregulation of the TSC-mTOR pathway in human disease. Nat Genet. 2005 Jan;37(1):19-24. PMID: #15624019#
Abraham RT. PI 3-kinase related kinases: ’big’ players in stress-induced signaling pathways. DNA Repair (Amst). 2004 Aug-Sep;3(8-9):883-7. PMID: #15279773#
Brader S, Eccles SA. Phosphoinositide 3-kinase signalling pathways in tumor progression, invasion and angiogenesis. Tumori. 2004 Jan-Feb;90(1):2-8. PMID: #15143962#
Vivanco I, Sawyers CL. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer. 2002 Jul;2(7):489-501. PMID: #12094235#
Cantley LC. The phosphoinositide 3-kinase pathway. Science. 2002 May 31;296(5573):1655-7. PMID: #12040186#
Testa, J. R.; Bellacosa, A. AKT plays a central role in tumorigenesis. Proc. Nat. Acad. Sci. 98: 10983-10985, 2001. #11572954#
Weaver SA, Ward SG. Phosphoinositide 3-kinases in the gut: a link between inflammation and cancer? Trends Mol Med. 2001 Oct;7(10):455-62. PMID: #11597520#
References
Knobbe CB, Reifenberger G. Genetic alterations and aberrant expression of genes related to the phosphatidyl-inositol-3’-kinase/protein kinase B (Akt) signal transduction pathway in glioblastomas. Brain Pathol. 2003 Oct;13(4):507-18. PMID: #14655756#