SLITRKs
Members of the SLITRKs family, such as SLITRK1, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins.
Most SLITRKs, but not SLITRK1, also have C-terminal regions that share homology with neurotrophin receptors. SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity.
Members
| SLITRK1 | SLITRK2 | SLITRK3 | SLITRK4 | SLITRK5 | SLITRK6 |
Pathology
SLITRK1 mutations in Tourette syndrome (MIM.137580)