MAPs
The assembly of microtubules is an essential step in neurogenesis. It is modulated by a family of molecules called microtubule-associated proteins (MAPs).
MAPs have been divided into 2 main groups by molecular mass, high molecular weight MAPs, which include MAP1A, MAP1B (157129), and MAP2 (157130), and another group of intermediate-sized proteins, which include the abundant tau MAPs.
MAP1B, also named MAP5, is a component of long cross-bridges between microtubules and is a filamentous molecule with a small spherical segment at one end.
Members
| MAP1A | MAP1B | MAP2 | MAP3 | MAP4 | MAP5 | MAP6 | MAP7 |
| MAPT (tau) |
Pathology
tau protein (TAU) associated diseases (taupathies)
See also
microtubules
References
Baas PW, Qiang L. Neuronal microtubules: when the MAP is the roadblock. Trends Cell Biol. 2005 Apr;15(4):183-7. PMID: #15817373#
Maiato H, Sampaio P, Sunkel CE. Microtubule-associated proteins and their essential roles during mitosis. Int Rev Cytol. 2004;241:53-153. PMID: #15548419#
Popov AV, Karsenti E. Stu2p and XMAP215: turncoat microtubule-associated proteins? Trends Cell Biol. 2003 Nov;13(11):547-50. PMID: #14573345#
Kinoshita K, Habermann B, Hyman AA. XMAP215 : a key component of the dynamic microtubule cytoskeleton. Trends Cell Biol. 2002 Jun ;12(6):267-73. PMID : #12074886#