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CR2
MIM.120650 1q32
Monday 9 January 2006
Complement component receptor-2 (CR2 or CD21) is the membrane protein on B lymphocytes to which the Epstein-Barr virus (EBV) binds during infection of these cells.
Functions
CD21 binds to Epstein Barr virus and breakdown products of complement component C3. CD21 forms a signaling complex with CD19, CD81 and CD225.
Expression in normal cells
mature B-cells follicular dendritic cells
- as CD23
Expression in tumors
follicular dendritic cell sarcoma (FDCS)
Use in pathology
Hodgkin lymphoma demonstrates disruption of follicular dendritic cell-germinal cell clusters (evaluated by CD21 and CD23).
See also
CDs