SRC
Src family protein tyrosine kinases (SFKs) play important roles downstream of integrin adhesion receptors, and they are necessary for the generation of "outside-in signals" that regulate cytoskeletal organization, cell motility and gene expression in response to cell adhesion.
Integrins
beta3-integrins and c-Src can interact directly, and this pool of c-Src is activated by cell adhesion to initiate outside-in signaling in platelets, osteoclasts and cells of the vasculature.
See also
Src kinases (SFKs)
Videos
The Rous Sarcoma Virus (RSV)
References
Avizienyte E, Frame MC. Src and FAK signalling controls adhesion fate and the epithelial-to-mesenchymal transition. Curr Opin Cell Biol. 2005 Oct;17(5):542-7. PMID: #16099634#
Shattil SJ. Integrins and Src: dynamic duo of adhesion signaling. Trends Cell Biol. 2005 Aug;15(8):399-403. PMID: #16005629#
Playford MP, Schaller MD. The interplay between Src and integrins in normal and tumor biology. Oncogene. 2004 Oct 18;23(48):7928-46. PMID: #15489911#
Yeatman TJ. A renaissance for SRC. Nat Rev Cancer. 2004 Jun;4(6):470-80. PMID: #15170449#