PROP1
Pathology
Mutations in the PROP1 gene are responsible for a high proportion of cases of multiple or combined anterior pituitary hormone deficiencies in humans.
- deficiency of growth hormone (GH)
- deficiency of thyroid-stimulating hormone (TSH)
- loss of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) responses to GnRH
- partial deficiency of corticotrophin (ACTH)