plasmablastic lymphoma
Definition: Plasmablastic lymphoma (PBL) is an aggressive lymphoma characterized by a terminally differentiated B-cell phenotype that usually occurs in the immunocompromised or elderly patients.
PBL are genetically characterized by frequent IG/MYC translocations and gains in multiple chromosomal loci. The oncogenic activation of MYC in these lymphomas may be an important pathogenetic element associated with EBV infection. (#20962620#)
Risk factors
EBV infection
HIV infection
Variants
pleomorphic lymphomas
Cytogenetics
t(2;5)(p23;q35) (#14576483#)
MYC rearrangements (#20348882#, #20962620#)
- MYC-associated plasmablastic lymphoma
See also
B-cell tumors
plasma cell dyscrasias
References
Plasmablastic lymphoma with MYC translocation: evidence for a common pathway in the generation of plasmablastic features. Taddesse-Heath L, Meloni-Ehrig A, Scheerle J, Kelly JC, Jaffe ES. Mod Pathol. 2010 Jul;23(7):991-9. PMID: #20348882# (Free)
IG/MYC rearrangements are the main cytogenetic alteration in plasmablastic lymphomas. Valera A, Balagué O, Colomo L, Martínez A, Delabie J, Taddesse-Heath L, Jaffe ES, Campo E. Am J Surg Pathol. 2010 Nov;34(11):1686-94. PMID: #20962620#
Adam P, Katzenberger T, Seeberger H, Gattenlohner S, Wolf J, Steinlein C, Schmid M, Muller-Hermelink HK, Ott G. A case of a diffuse large B-cell lymphoma of plasmablastic type associated with the t(2;5)(p23;q35) chromosome translocation. Am J Surg Pathol. 2003 Nov;27(11):1473-6. PMID: #14576483#