TLX1
MIM.186770 10q24
Role in development
splenic organogenesis
Pathology
t(10;14)(q24;q11) (10q24 and 14q11) or t(7;10)(q35;q24) (7q35 and 10q24) in childhood T-cell acute leukemia
- Up to 7% of childhood T-cell acute leukemia is accompanied by a translocation involving 10q24 as a breakpoint, either t(10;14)(q24;q11) or t(7;10)(q35;q24).
- The gene adjacent to the 10q24 region is transcriptionally activated after translocation to the proximity of either TCRD at 14q11 (MIM.186810) or TCRB at 7q35 (MIM.186930).
- TLX1 is translocated
- to TCRD at 14q11 (MIM.186810) by t(10;14)(q24;q11)
- to TCRB at 7q35 (MIM.186930) by t(7;10)(q35;q24)
See also
TLXs
References
Hatano, M.; Roberts, C. W. M.; Minden, M.; Crist, W. M.; Korsmeyer, S. J. : Deregulation of a homeobox gene, HOX11, by the t(10;14) in T cell leukemia. Science 253: 79-82, 1991. PubMed ID : #1676542#