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CASP8

Pathology

- CASP8 germline mutations in autoimmune lymphoproliferative syndrome type 2b (ALPS2b)

- A common coding variant in CASP8 is associated with breast cancer (mmary carcinomas) risk (#17293864#)

- Frequent promoter hypermethylation of RASSF1A and CASP8 in neuroblastoma (#17064406#)

See also

- CASPs and CASP10
- autoimmune lymphoproliferative syndrome

References

- Lazcoz P, Munoz J, Nistal M, Pestana A, Encio I, Castresana JS. Frequent promoter hypermethylation of RASSF1A and CASP8 in neuroblastoma. BMC Cancer. 2006 Oct 25;6:254. PMID: #17064406#

- Cox A, Dunning AM, Garcia-Closas M, Balasubramanian S, Reed MW et al. ; A common coding variant in CASP8 is associated with breast cancer risk. Nat Genet. 2007 Feb 11; PMID: #17293864#