cervical squamous cell carcinoma
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Cancer of the uterine cervix is the second largest cause of cancer deaths in women. Cervical carcinomas develop as a result of multiple genetic alterations.
Allelotyping (LOH frequency > 25%) (#9699535#)
| 3p21 LOH | ||
| 4p16 LOH | 25%-92% | #11006038# |
| 5p15 LOH | ||
| 6p LOH | ||
| 6q14 LOH | ||
| 6q22 LOH | ||
| 11q23 LOH | ||
| 15q21 LOH | ||
| 17p13 LOH | ||
| 18q22-qter LOH | ||
| 19q13 LOH | ||
| Xq LOH |
Regional amplifications
3q24-28 amplification (90%)
8q24.3 amplification
11q22.2 amplification
20q13 amplification
DNA repair
microsatellite instability (MSI): 7% (#9699535#)
Overexpressed genes (#17243165#)
EPHB2 (1p36), CDCA8 (1p34.3), AIM2 (1q22-23), RFC4, MUC4, and HRASLS (3q27-29), SKP2 (5p12-13), CENTD3 (5q31.3), PTK2, RECQL4 (8q24), MMP1 and MMP13 (11q22.2), AKT1 (14q32.3), ABCC3 (17q21-22), SMARCA4 (19p13.3) LIG1 (19q13.3), UBE2C (20q13.1), SMC1L1 (Xp11), KIF4A (Xq12), TMSNB (Xq22), and CSAG2 (Xq28)
Videos
Cervical squamous cell carcinoma by Washington Deceit (1)
Cervical squamous cell carcinoma by Washington Deceit (2)
References
The natural history of cervical HPV infection: unresolved issues. Ciaran B. J. Woodman, Stuart I. Collins and Lawrence S. Young. Nature Reviews Cancer 7, 11-22 (January 2007)
Narayan G, Bourdon V, Chaganti S, Arias-Pulido H, Nandula SV, Rao PH, Gissmann L, Durst M, Schneider A, Pothuri B, Mansukhani M, Basso K, Chaganti RS, Murty VV. Gene dosage alterations revealed by cDNA microarray analysis in cervical cancer: identification of candidate amplified and overexpressed genes. Genes Chromosomes Cancer. 2007 Apr;46(4):373-84. PMID: #17243165#
Roden R, Wu TC. How will HPV vaccines affect cervical cancer? Nat Rev Cancer. 2006 Oct;6(10):753-63. PMID: #16990853#
Jones EE, Wells SI. Cervical cancer and human papillomaviruses: inactivation of retinoblastoma and other tumor suppressor pathways. Curr Mol Med. 2006 Nov;6(7):795-808. PMID: #17100604#